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OTUD6A activates DNA repair. 1 / 1
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"We next assessed the role of OTUD6A in DNA replication reinitiation after HU treatment, and the results showed that the DNA replication reinitiation rate was decreased in OTUD6A-knockdown T24 cells after release from HU (Fig. 6i and Supplementary Fig. 10j), suggesting that inhibition of OTUD6A increases DNA damage and reduces DNA repair caused by HU in BCa cells.The ATR-Chk1 pathway is a key signalling axis driving the DDR [2], and CDC6 has been identified as a critical regulator of ATR-Chk1 activation [2, 8, 9, 42]."