IndraLab

Statements

USP13 inhibits STING1. 2 / 2
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"In this sense, USP13 inhibition may activate the STING pathway along with innate immunity, which may provide a synergetic effect with ICIs."
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"The K27 linked-polyubiquitin chains are removed by the deubiquitinating enzyme (DUB) ubiquitin-specific protease 13 (USP13), which inhibits the basal activity of MITA in a manner dependent on blocking its recruitment of TBK1 (Sun et al., 2017)."
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