IndraLab

Statements

USP10 deubiquitinates PCNA. 5 / 5
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"Moreover, USP10 could induce PCNA deubiquitination to promote HCC cell growth."
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"Recent research has shown that PCNA is also modified by ISG15, and ISGylation of PCNA recruits USP10 to deubiquitinate PCNA, thereby regulating PCNA ubiquitination under UV irradiation induced stress."
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"And USP10 could strengthen cell proliferative and migratory abilities through deubiquitinating PCNA."
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"An interesting study has recently shown that the deubiquitylation of mammalian PCNA, at least in the context of DNA damage induced by ultraviolet irradiation (UV), is aided by the deubiquitylating activity of USP10."
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"This modification in turn recruits USP10 that de-ubiquitylates PCNA in order to block TLS and resume normal replication."
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