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Statements

OTULIN inhibits IKBKG. 6 / 7
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"By contrast, OTULIN acts specifically on linear ubiquitin linkages and prevents association of NEMO with ubiquitinylated RIPK1, which in turn thwarts the colocalization of TAK1 and IKK complexes, thus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Accordingly, depletion of OTULIN enhanced the recruitment of NEMO to Met1 ubiquitinated RIPK2 in response to L18-MDP, whereas NEMO recruitment was inhibited by OTULIN overexpression."
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"Further, the Porcine reproductive and respiratory syndrome virus induces the expression of OTULIN, which reduces the linear ubiquitinylation of NEMO and inhibits NF-κB-mediated type I IFN production [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTULIN is upregulated in a PRRSV infection model and interacts with the PRRSV non-structural protein 11 ( Nsp11 ) to decrease Ub levels on NEMO and to block NF-kappaB activation and IFN-regulatory transcription factor 3 ( IRF3 ) - mediated type-I IFN production [ 22 ] ."
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"The presence of OTULIN, but not HA-OTULIN , abrogated the recovery of FLAG-NEMO (Fig. 4E) and GFP-VANGL2 by GST-UBAN (Fig. 4F)."
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"Overexpression of OTULIN inhibits TNF-alpha-induced NF-kappaB signaling by preventing the association of NEMO with polyubiquitinated RIP1 (Fiil et al., 2013; Keusekotten et al., 2013)."
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