IndraLab

Statements

CHUK binds IKBKB and KCNG1. 4 / 4
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sparser
"Instead, NEMO is required for mediating the interaction between K13 and IKK1 and IKK2."
22590573
sparser
"As shown in xref , while interaction of K13 with NEMO, IKK1, and IKK2 was readily detected in samples immunoprecipitated with Flag antibody from wild-type Jurkat cells, no significant interaction between K13 and IKK1 or IKK2 was observed in the NEMO-deficient Jurkat cells, Stimulation of cells with TNFα or IL-1 induces recruitment of IKK1 and IKK2 to NEMO and their subsequent phosphorylation and activation xref , xref ."
22590573
sparser
"Therefore, to explain the role of NEMO in K13-inducd NF-κB activation, we tested the hypothesis that NEMO mediates the interaction between K13 and IKK1 and IKK2."
22590573
sparser
"Conversely, the KSHV protein K13 interacts with the IKKα-IKKβ complex such that NFκb is activated 98 ."
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