IndraLab

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Modified SHOX2 increases the amount of HCN4. 3 / 3
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"In our previous study, it was confirmed that overexpression of Shox2 in cMSCs could upregulate HCN4 expression, and its level was significantly increased by co-culture induction."
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"The results demonstrated that overexpression of Shox2 significantly increased the expression of Tbx3, HCN4 and Cx45 at the mRNA (P < 0.05) and protein levels, and the difference increased markedly when co-cultured with RNCMs (XREF_FIG and XREF_FIG)."
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"At E10.5, despite of an unaltered Shox2 expression in the transgenic SAN, we observed a down-regulation of Tbx3, and a reduced but not absent Hcn4 expression (XREF_FIG), indicating that Shox2 does not regulate the expression of Tbx3 and Hcn4 directly in the SAN, consistent with the observation that Shox2 ectopic expression does not induce ectopic expression of Tbx3 and Hcn4 in the developing heart."
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