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COPS5 activates ERN1. 2 / 2

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"Nevertheless, our data suggested the possibility that JAB1-IRE1alpha binding was increased to suppress UPR when the stimulus was weak, while JAB1 rapidly dissociated from IRE1alpha to allow IRE1alpha [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Upon ER stress, JAB1 dissociates from IRE1alpha, allowing IRE1alpha to splice XBP1 mRNA into XBP1s, suggesting that JAB1 inhibits IRE1alpha through its binding 55."

28550308

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IndraLab

Statements

COPS5 activates ERN1. 2 / 2

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