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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 activates ERN1. 2 / 2

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"Upon ER stress, JAB1 dissociates from IRE1alpha, allowing IRE1alpha to splice XBP1 mRNA into XBP1s, suggesting that JAB1 inhibits IRE1alpha through its binding 55."

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"Nevertheless, our data suggested the possibility that JAB1-IRE1alpha binding was increased to suppress UPR when the stimulus was weak, while JAB1 rapidly dissociated from IRE1alpha to allow IRE1alpha [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...