IndraLab

Statements


USP4 inhibits degradation. 3 / 3
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"USP4, a member of the USP family, inhibits the degradation of target proteins that depend on the ubiquitin proteasome pathway."

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"Because USP4 inhibits ubiquitination-mediated HDAC2 degradation, we hypothesized that USP4 inhibits p53 functions through HDAC2."

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"In addition, proteasome inhibition by the addition of MG132 induced a significant increase in the PDCD4 expression level ( xref ), suggesting that USP4 inhibits PDCD4 degradation."