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KCNH2 inhibits KCN. 9 / 9
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"Conversely, downregulation of KCNH2 gene expression reduces the hERG potassium channel, essential for cardiac repolarization."
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"HERG antagonists block the HERG channel, inhibit the proliferation and migration of cancerous cells, and inhibit the potassium channel of myocardial cells, resulting in severe arrhythmia (58,59)."
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"In contrast with findings described by others (Matsa etal, 2011), hERG modulation by LUF7346 completely reversed the severe effects of the potassium channel blocker AST in LQT2 N996I hiPSC-CMs, confirming the efficacy of LUF7346 compared to other molecules reported so far in the literature."
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"Furthermore, Zwi et al. (2009) reported that, in addition to CACNA1C and KCNH2, hiPS-CMs expressed the genes for the slowly activating delayed rectifier potassium channel KCNQ1 ( I ks ), which also co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20156482
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"As shown in Fig. 7 , KPH2f showed no inhibitory effects on hERG potassium channel at 50 μM, while the positive control cisapride inhibited the potassium channel completely at a concentration of 1 μM ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Using Xenopus oocytes, Choi et al. [40] found that hERG potassium channel Ser631Cys mutation eliminated the regulatory effect of ginsenoside Rg3 on HERG, suggesting that ginsenoside Rg3 may be antagon[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG inhibition of potassium channels mainly leads to QT syndrome, leading to ventricular arrhythmia. xref For this reason, many drugs were restricted in use."
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"This is primarily caused by the blockage of the human ether-à-go-go related gene (hERG) potassium channel, which is a voltage-gated ion channel that allows a delayed, sustained K efflux following cardiac depolarization."
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"Drugs like dofetilide that selectively block the potassium channel encoded by the human ether-à-go-go-related gene ( hERG ) inhibit a repolarising outward potassium current (IK R ) in ventricular card[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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