IndraLab

Statements

KCNH2 inhibits KCN. 2 / 2
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"In contrast with findings described by others (Matsa etal, 2011), hERG modulation by LUF7346 completely reversed the severe effects of the potassium channel blocker AST in LQT2 N996I hiPSC-CMs, confirming the efficacy of LUF7346 compared to other molecules reported so far in the literature."
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"This is primarily caused by the blockage of the human ether-à-go-go related gene (hERG) potassium channel, which is a voltage-gated ion channel that allows a delayed, sustained K efflux following cardiac depolarization."
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