IndraLab

Statements


USP8 activates Death. 3 / 3
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"Silencing or pharmacological inhibition of USP8 deubiquitinase, relevant in particular to the stability of RTKs such as EGFR and MET, was shown to induce death of gefitinib resistant NSCLC cells in vitro and in vivo [XREF_BIBR]."

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"USP8 siRNAs reduced viability and increased death in cSCC lines but had little effect in normal skin cells (XREF_FIG a)."

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"In brief, USP13 and USP8 promote α-Syn-related pathology, and the knockdown of USP13 and USP8 reduces α-Syn-induced DA neuronal death."