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KCNA3 activates apoptotic process. 12 / 12
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"Blockade of Kv1.3 with Stichodactyla helianthus (Shk)-170, a selective peptide inhibitor of Kv1.3, inhibited the apoptosis of primary hippocampal neurons induced by irradiated BV2 microglia in the co-culture system [74]."
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"The specific Kv1.3 channel inhibitor clofazimine can inhibit cancer cell proliferation and induce cancer cell apoptosis through the mitochondrial pathway (9)."
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"In addition to complement-dependent cytotoxicity, rituximab also stimulates FcγRIIB receptors and inhibits Kv1.3 channels, which leads to apoptosis in malignant B lymphocytes (Wang et al., 2012)."
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"Up-regulation of lncRNA kcna3 inhibited cell growth, carcinogenesis and promoted cell apoptosis, while up-regulation of YAP1 promoted cell growth, carcinogenesis and inhibited cell apoptosis."
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"Moreover, the repression of cell growth and carcinogenesis and promotion of cell apoptosis induced by Lenti-kcna3 up-regulation were impaired when YAP1 was over-expressed."
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"If this were the case , the oscillations in K + and , consequently , differential Ca2 + triggers would determine whether Kv1.3 promotes apoptosis or cell growth29 ,32 , and KCNE4 would determine the balance between these two entities ."
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"Previously, it was discussed that Kv1.3 on a cell membrane is involved in cell proliferation, and the Kv1.3 channel on mitochondria is involved in the regulation of cell apoptosis, among which Kv1.3 on mitochondria is considered as a new tumor marker, and decreased Kv1.3 expression on mitochondria can induce the apoptosis of tumor cells (Checchetto et al., 2019)."
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"Besides, our study demonstrated that cell growth and tumorigesis repression and cell apoptosis promotion mediated by lncRNA kcna3 over-expression were all weakened when up-regulated YAP1, suggesting t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The specific Kv1.3 channel inhibitor clofazimine, as a membrane-permeable small molecule organic compound, can inhibit cancer cell proliferation and induce cancer cell apoptosis through the mitochondrial pathway (9)."
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"Therefore, Kv1.3 can increase its killing effect by regulating T lymphocyte activity or inducing the apoptosis of liver tumor cells."
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"Kv1.3 expression by transfection resensitized these cells to the apoptosis signal and promoted the apoptosis of CTLL-2 cells (Gulbins et al., 2010)."
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"If this were the case, the oscillations in K and, consequently, differential Ca triggers would determine whether Kv1.3 promotes apoptosis or cell growth , and KCNE4 would determine the balance between these two entities.Our work further investigated the consequences of KCNE4 suppression in dendritic cells."
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