IndraLab

Statements

USP9X activates JAK2. 2 / 2
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"We further found that activated JAK2 may be naturally suppressed in 25% of CRLF2 pos DS-ALLs by loss-of-function aberrations in USP9X, a deubiquitinase previously shown to stabilize the activated phosphorylated JAK2."
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"USP9X positively regulated the JAK2 and STAT3 pathway to promote the malignant progression of liver cancer cells."
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