IndraLab

Statements

Hydroxychloroquine inhibits viral life cycle. 28 / 28
| 28
eidos
"Thus , CQ and HCQ might induce cellular iron starvation , inhibit the viral life cycle , and / or dampen immunity ( Figure 2 , step 2B ; Quiros Roldan et al ., 2020 ) ."
33693723
eidos
"CQ and HCQ may inhibit the release of IL-6 , IL-1B , and TNF-a and so cause a decrease in hepcidin and inhibit viral replication [ 32 ] ."
32901413
eidos
"However , HCQ alone failed to reduce viral replication in HIV-infected patients [ 55 ] ."
| PMC
eidos
"1 This may be because both CQ and HCQ have been postulated to reduce viral replication in other coronavirus infections.2 ,3 According to a recent systematic review , there are almost 20 ongoing randomized controlled clinical trials on both medications for treatment of COVID-19 and all of them are in China ."
32349115
eidos
"Also , recent in vitro study showed that HCQ and CQ could decrease the viral replication in a concentration-dependent manner ."
| PMC
eidos
"Moreover , no association of ethnicity or smoking with blood hydroxychloroquine concentrations was found.19 Daily dose of hydroxychloroquine In vitro , hydroxychloroquine had antiviral activity and decreased viral replication in a concentration-dependent manner ."
33729874
eidos
"49 In a Syrian hamster model that allows SARS-CoV-2 replication to high titers in the lung leading to bronchopneumonia and lung inflammation , HCQ mildly reduced viral replication in the lungs , but this did not lead to any reduction in lung pathology ."
33855275
eidos
"However , the persistent positivity of the sputum samples for SARS-CoV-2 throughout the course of treatment ( Fig. 5 ) indicated that the viral replication could not be completely suppressed by hydroxychloroquine and favipiravir ."
| PMC
eidos
"Further , though an ex vivo study demonstared that HCQ and CQ reduce viral replication , a recent study suggested that HCQ treatment showed no benefit in hamsters and macaques infected with SARS-CoV-2 [ 79 ] ."
| PMC
eidos
"In vitro , hydroxychloroquine had antiviral activity and decreased viral replication in a concentration-dependent manner ."
33729874
eidos
"Hydroxychloroquine combination with nitazoxanide , lopinavir , or ritonavir A synergistic combination of HCQ and nitazoxanide was reported by Padmanabhan , through inhibiting the viral replication by HCQ and regulating innate immunity by nitazoxanide ."
34028468
eidos
"Fig. 3 : Possible sites of inhibition of viral replication by combination of HCQ , Zn + + and MTX ."
| PMC
eidos
"1 This may be because both CQ and HCQ have been postulated to reduce viral replication in other coronavirus infections ."
32349115
eidos
"49 In a Syrian hamster model that allows SARS-CoV-2 replication to high titers in the lung leading to bronchopneumonia and lung inflammation , HCQ mildly reduced viral replication in the lungs , but this did not lead to any reduction in lung pathology.50 HCQ treatment did not protect hamsters from contracting the virus from close contact with another infected hamster and did not reduce resulting viral titers.50 CQ also inhibits other coronaviruses ."
33855275
eidos
"11 Clinical trials testing of the effect of camostat on COVID-19 are now ongoing ( NCT04321096 ) ; ( b ) use of chloroquine / hydroxychloroquine do inhibit viral replication , as demonstrated in different preclinical models ."
32658389
eidos
"Chloroquine and hydroxychloroquine were found to decrease the viral replication in a concentration-dependent manner ."
32150618
eidos
"Recently , CQ and HCQ were found to decrease viral replication in a dose-dependent manner in SARS-CoV-2-infected Vero cells in vitro , and the EC50 value for CQ was 5.47 muM at 48 h ( 5 ) ."
32958120
eidos
"In this context , it has been proposed that the clinically approved serine protease inhibitor camostat mesylate might decrease SARS-CoV-2 entry in vitro.11 Clinical trials testing of the effect of camostat on COVID-19 are now ongoing ( NCT04321096 ) ; ( b ) use of chloroquine / hydroxychloroquine do inhibit viral replication , as demonstrated in different preclinical models ."
32658389
eidos
"Chloroquine and hydroxychloroquine blocked viral replication at multiple points in vitro experiments so these drugs have been found to be effective against SARS-CoV-2 ."
32929317
eidos
"The 4-aminoquinolines , chloroquine ( CQ ) , and its hydroxyl analog hydroxychloroquine ( HCQ ) have been found to disrupt the viral replication and infectivity ."
32960061
eidos
"In vitro studies showed that HCQ blocks viral replication by inhibition of cell entry of SARS-CoV-2 and prevents virus-cell fusion by interfering with glycosylation of ACE2 receptor and its binding with spike protein ."
33196003
eidos
"HCQ was also reported to inhibit viral replication [ 16 ] ."
32923679
eidos
"Quinine , chloroquine , and hydroxychloroquine also belong to quinolines and have been recommended for the early phase of COVID-19 treatment to prevent viral replication ( Li and Cheng , 2020 ) ."
33584306
eidos
"Studies performed in vitro showed that chloroquine and hydroxychloroquine both decreased the viral replications in a dose-dependent manner when given at treatment dosing , however the inhibition rate was much lower when pretreated with hydroxychloroquine and chloroquine suggesting less of an effect if given as prophylaxis prior to infection [ 16 ] ."
| PMC
eidos
"In summary , while protease inhibitors may decrease viral burden , inhaled nitric oxide may reduce V / Q mismatch , anticytokine therapy may treat cytokine storm or prevent its progression , and immunomodulators like chloroquine / hydroxychloroquine may inhibit viral replication , RRx-001 may serve as an all-in-one therapy , which improves cardiopulmonary function , decreases viral burden and reduces the systemic inflammatory response ."
| PMC
eidos
"Chloroquine and hydroxychloroquine have been reported to inhibit viral replication [ 37 ] , and also decrease the release of pro-inflammatory cytokines [ 38 ] ."
33180935
eidos
"Besides , HCQ impedes viral replication by blocking the p38 MAPK cascade ."
33364965
eidos
"Effects of chloroquine in combination with other antiretrovirals As chloroquine / hydroxychloroquine probably inhibits viral replication by a mechanism different from those of currently used antiretroviral drugs , its application has been studied in combination with other antiretroviral drugs ."
14592603