IndraLab

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Lithium(1+) inhibits NFKB1. 6 / 6
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"We thus initially thought that the induction of p105 degradation and Tpl2 activation by lithium might be due to inhibition of GSK3beta."
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"Lithium activates Tpl2 by inducing degradation of p105, an NF-kappaB precursor protein that functions as a physiological inhibitor of Tpl2."
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"A recent study has shown that long-term use of lithium can reduce p105 content in macrophages and inhibit lipopolysaccharide (LPS)-mediated NF-kappaB activation, which results in macrophage apoptosis 43."
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"Lithium induces degradation of p105 and liberation of Tpl2."
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"Lithium, an adjuvant antidepressant drug, has been shown to induce degradation of p105, an NF-κB precursor protein, and may function as a pharmacological inhibitor of the p105-TNIP2-TPL-2 ternary comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A major signaling function of lithium is to stimulate degradation of the NF-kappaB1 precursor protein p105."
19159680