IndraLab

Statements

USP11 inhibits cell growth. 5 / 5
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"Furthermore, down‐regulation of USP11 significantly suppressed HepG2 cell growth (Figure 4C) and chemoresistance (Figure 4D), and clonogenic assay showed that USP11 silencing greatly suppressed the colony‐forming ability of these HCC cells (Figure 4E)."
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"To determine whether USP11 loss inhibits PCa cell growth via effects on AR and/or c-Myc, we reexpressed AR, c-Myc, or both in USP11-KD VCaP cells to levels seen in control cells (Fig. 6A)."
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"These findings indicate that USP11 KD inhibits PCa cell growth regardless of PTEN status and suggest that USP11 targets other substrate(s) to promote PCa cell growth."
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"Furthermore, our results show that knockdown of USP11 promotes cell growth, migration, and invasion in a YAP dependent manner."
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"USP11 suppresses tumor cell growth via the regulation of Mgl-1, and the suppression requires RanBPM expression."
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