IndraLab

Statements

USP22 activates BMI1. 10 / 10
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"USP22 also upregulates BMI-1 and may upregulate Survivin via BMI-1 overexpression (20)."
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"Moreover, WT-USP22 prolonged GFP-BMI1 half-life compared with that in cells transfected with control vector or CI-USP22."
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"17 About the possible relationship among BMI1, EZH2, and USP22, it has been reported that USP22 increases BMI1: in gastric cancer, USP22 inactivation decreases the neoplasm growth, while high levels of BMI1 accelerate the cell cycle via INK4a/ARF and AKT."
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"USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein."
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"Ma et al (19) demonstrated that USP22 maintained gastric cancer cell stemness and promoted gastric cancer progression by stabilizing the Bmi-1 protein (19)."
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"USP22 promotes stem cell-like features of NSCLC cells by regulating BMI1 signaling (78)."
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"An in vitro study showed that the upregulation of USP22 mediated the enhanced expression of BMI1 and Cyclin D2, and was responsible for increased cell proliferation and the metastatic behavior of colon cancer cells ."
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"Previous studies have confirmed that USP22 can promote the biological process of NSCLC cells by regulating BMI-1 and AKT signaling pathway [XREF_BIBR]."
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"Additionally, USP22 silencing led to down-regulated BMI1."
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"In this study, we demonstrated that USP22 mediated protein stabilization of BMI1 promotes gastric CSC stemness maintenance and GC progression, thereby providing a rationale for USP22 targeting as a potential therapeutic approach against GC."
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