IndraLab

Statements

USP22 activates BMI1. 6 / 6
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"Moreover, WT-USP22 prolonged GFP-BMI1 half-life compared with that in cells transfected with control vector or CI-USP22."
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"In this study, we demonstrated that USP22 mediated protein stabilization of BMI1 promotes gastric CSC stemness maintenance and GC progression, thereby providing a rationale for USP22 targeting as a potential therapeutic approach against GC."
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"Additionally, USP22 silencing led to down-regulated BMI1."
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"Previous studies have confirmed that USP22 can promote the biological process of NSCLC cells by regulating BMI-1 and AKT signaling pathway [XREF_BIBR]."
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"USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein."
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"An in vitro study showed that the upregulation of USP22 mediated the enhanced expression of BMI1 and Cyclin D2, and was responsible for increased cell proliferation and the metastatic behavior of colon cancer cells ."
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