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SNCA inhibits UCHL1. 4 / 4
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"We also speculate that extracellular wild-type UCH-L1 plays some physiological role.In conclusion, this study showed that PD associated mutations in alpha-synuclein and UCH-L1 inhibit the unconvention[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In Figs. 4 and 5, we showed that alpha-synuclein and huntingtin mutations decreased the secretion of endogenous UCH-L1."
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"Furthermore, under pathological conditions, when alpha-syn was overexpressed, blocking UCH-L1 by LDN resulted in an increase in LC3-II, which was not observed in control cells, suggesting a differential role of UCH-L1 activity under normal and pathological conditions."
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"Alpha-Synuclein and huntingtin mutations also inhibit the secretion of endogenous UCH-L1."
21693148