IndraLab

Statements

SMURF1 inhibits USP25. 4 / 4
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"Smurf1 overexpression decreases USP25 protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 degradation."
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"Additionally, Smurf1 mediated degradation of USP25 is via promoting the K48-linkage polyubiquitination of USP25 in an ubiquitin proteasome dependent pathway."
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"SMURF1 was then recruited to PRMT7 in a MAVS-dependent manner to catalyze the K48-linked polyubiquitination of PRMT7 to ensure its timely proteasomal degradation and subsequent RIG-I-MAVS activation, while SMURF1 degraded MAVS, TRAF3, TRAF6, or USP25 in later viral infection stages to avoid excessive RLR signaling activation (146)."
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"Notably, SMURF1 was shown to induce the K48-dependent proteasomal degradation of USP25, MAVS, TRAF3, and TRAF6 upon infection, thereby negatively regulating innate immune signaling events ( Qian et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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