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USP22 activates SIRT1/AKT/MRP1. 2 / 2

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"Together, these results indicate that USP22 could promote the MDR in HCC cells by activating the SIRT1/AKT/MRP1 pathway."

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"USP22 up-regulates the SIRT1/AKT/MRP1 signaling pathway and promotes the efflux of 5-Fluorouracil (5-FU), leading to the treatment resistance of HCC [17]."

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IndraLab

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USP22 activates SIRT1/AKT/MRP1. 2 / 2

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