IndraLab

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"Haloperidol induced c-fos was augmented in the striatum and pituitary, but reduced in the frontal cortex by chronic lithium treatment."

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"Globus pallidus lesions inhibit the induction of c-Fos by haloperidol in the basal ganglia output nuclei in rats."

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"Consistently, haloperidol-induced VCMs and decrease in the number of c-Fos + /ppENK + iMSNs were also mitigated by intrastriatal injection of CGS 21680A."

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"Muscarinic receptor antagonists suppressed haloperidol induced c-fos expression throughout the shell and in the mid-level of the core of the nucleus accumbens while A (2) and H (3) receptor antagonists did not.We found that the muscarinic and H (3) receptor antagonists suppress the induction of c-fos by haloperidol in the dorsolateral aspect of the striatum, an area implicated in the development of extrapyramidal motor symptoms following chronic haloperidol treatment."

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"A 21-day treatment with haloperidol increased the number of vacuous chewing movements (VCMs) and decreased the number of c-Fos + /ppENK + iMSNs in the dorsal striatum."