IndraLab

Statements

USP8 inhibits erastin. 2 / 2
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reach
"These results indicated that USP8 may be a specific negative regulator of ferroptosis, instead of apoptosis or necrosis modulator.To confirm whether USP8 suppression enhances the anti-cancer activity of erastin in vivo, we stably knocked down USP8 in NCI-H1299 cell line by lentiviral vector."
37051673
reach
"Then we observed increased ubiquitination of SQSTM1 under erastin treatment, which was significantly reduced by USP8, suggesting USP8-regulated SQSTM1 ubiquitination was involved in USP8-mediated ferroptosis (Fig. 2G)."
37051673