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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

UCHL1 activates transport. 2 / 2

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"We previously demonstrated that impaired retrograde transport in the presence of Abeta occurs through an ubiquitin dependent mechanism, and that the deubiquiting enzyme UCHL-1 restores retrograde transport of BDNF and TrkB [XREF_BIBR]."

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"We found that UCHL-1 restored BDNF and TrkB transport not only in the presence of Abeta but also with IL-1beta, suggesting the two agents share a common mechanism of interfering with ubiquitination dependent trafficking mechanisms."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...