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UCHL1 activates transport. 2 / 2

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"We previously demonstrated that impaired retrograde transport in the presence of Abeta occurs through an ubiquitin dependent mechanism, and that the deubiquiting enzyme UCHL-1 restores retrograde transport of BDNF and TrkB [XREF_BIBR]."

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"We found that UCHL-1 restored BDNF and TrkB transport not only in the presence of Abeta but also with IL-1beta, suggesting the two agents share a common mechanism of interfering with ubiquitination dependent trafficking mechanisms."

28153028

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UCHL1 activates transport. 2 / 2

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