IndraLab

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USP15 deubiquitinates FABPs. 3 / 3
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"It is also strongly supposed that FABPs and perilipins are deubiquitinated by USP15 and that their enhanced stability synergistically contributes to increased lipid accumulation and inflammation in the development of NAFLD/NASH.An FPC diet is used to induce features of metabolic and hepatic NASH characteristics."
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"To further confirm the deubiquitination of FABPs and perilipins mediated by USP15, we used TUBE-agarose beads (tandem ubiquitin-binding entities) to identify and isolate total ubiquitinated proteins."
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"USP15 can deubiquitinate FABPs and Perilipin proteins, thereby increasing their stability and boosting lipid accumulation (133).5 Conclusion and prospects."
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