IndraLab

Statements

Nilotinib inhibits KCNH2. 3 / 3
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"However, nilotinib is a potent inhibitor of hERG, a cardiac K + channel whose inhibition increases risk of sudden death."
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"Patch-clamp recordings revealed significant reductions of hERG current densities by nilotinib or vandetanib after chronic incubation with hERG-HEK293 cells in addition to the acute inhibition ."
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"Previous studies have shown that both nilotinib and vandetanib acutely block the hERG channel ( Lee et al., 2018; Shah et al., 2013 )."
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