IndraLab

Statements

Nilotinib inhibits KCNH2. 4 / 4
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"Nilotinib, a second generation Bcr-Abl inhibitor, led to increased ROS generation, caspase activation, hERG block, and an arrhythmic beat pattern."
23707608
eidos
"Patch-clamp recordings revealed significant reductions of hERG current densities by nilotinib or vandetanib after chronic incubation with hERG-HEK293 cells in addition to the acute inhibition ."
35680041
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"However, nilotinib is a potent inhibitor of hERG, a cardiac K + channel whose inhibition increases risk of sudden death."
32292555
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"Western blot analysis showed that nilotinib and vandetanib decreased mature hERG protein (155-kDa) expression, in a greater extent than that of the immature form (135-kDa)."
35680041