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KCNQ1 inhibits exocytosis. 2 / 2
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"siRNA knockdown of KCNQ1 in human islets enhanced depolarization induced exocytosis, whereas pharmacological inhibition in INS-1 cells did not affect basal, tolbutamide or GSIS."
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"siRNA silencing of KCNQ1 (64 +/- 3% [n = 3] reduction of mRNA, 74% protein reduction as measured by immunocytochemistry, and 54% reduction as measured by Western blot) likewise enhanced exocytosis from 59 +/- 9 fF/pC to 99 +/- 15 fF/pC (P = 0.011) (XREF_FIG)."
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