IndraLab

Statements

OTUD4 activates cell population proliferation. 5 / 5
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"In vivo assays substantiate that OTUD4 deletion, when combined with regorafenib, drastically reduces tumor proliferation, showcasing potent synergistic antitumor activity."
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"Hence, we conclude that OTUD4 does affect the activation of the MAPK signaling pathway through the regulation of CDK1, and promote the proliferation and invasion ability of GBM cells."
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"Moreover, we provided in vitro and in vivo evidence that OTUD4 promotes the proliferation and invasion of GBM cells."
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"OTUD4 promotes GBM cell proliferation and invasion."
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"In addition, overexpression of OTUD4 notably promoted the proliferation and invasion of LN229 cells (Supplementary Fig. 2G–I, Supplementary Fig. 3E–G)."
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