IndraLab

Statements

USP22 binds IPO7. 5 / 5
| 4 1
sparser
"Together, the above results indicate that Importin–7–AR–USP22 might form a relatively stable complex, even if AR and USP22 may competitively bind to Importin-7."
37391429
reach
"Mechanistically, through co-immunoprecipitation, immunofluorescence, and nuclear-cytoplasmic protein separation experiments, we discovered that AR and USP22 can bind to Importin-7 as cargoes to promote BC progression."
37391429
reach
"Importin-7 binds to AR and USP22."
37391429
reach
"In addition, our immunofluorescence analysis showed that Importin-7 binds to AR or USP22 in both the nucleus and cytoplasm (Fig. 4C–E), suggesting that Importin-7 may regulate the nuclear translocation of AR and USP22.Next, we conducted a more in-depth study of the Importin-7–AR–USP22 complex by the treatment of AR inhibitor (enzalutamide) or AR ligands, including DHT and synthetic androgen R1881."
37391429
reach
"Together, the above results indicate that Importin–7–AR–USP22 might form a relatively stable complex, even if AR and USP22 may competitively bind to Importin-7."
37391429