IndraLab

Statements

KCNA3 activates potassium(1+). 3 / 3
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"When expressed into Xenopus oocytes, HLK3 K+ channel (Kv1-3) induced a slowly inactivating voltage dependent K+ current."
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"Our findings reveal that potassium efflux mediated by the Kv1.3 channel is essential for TLR3/4 activation and suggest that pharmacological inhibition of Kv1.3 may help to treat type I IFN related autoimmune diseases and bacterial infections."
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"Due to its TCR induced expression and previously described role in T cell function XREF_BIBR, we hypothesized that enforced expression of Kcna3 may increase potassium efflux with a resultant increase in intratumoural T cell effector function."
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