IndraLab

Statements

BAP1 inhibits EZH2. 11 / 11
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"BAP1 loss leads to reduced L3MBTL2 stability and increased EZH2 transcriptional output (XREF_FIG)."
26437366
eidos
"BAP1 loss also up-regulates the expression of EZH2 , a Polycomb Repressive Complex-2 ( PRC2 ) component involved in epigenetic silencing ( 59 ) and oncogenic pathways ( 60 ) , suggesting sensitivity of BAP1-deficient MPM tumors to EZH2 inhibition ."
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"Indeed , we observed that loss of BAP1 results in elevated EZH2 expression and increased H3K27me3 levels , and knock-down of Ezh2 leads to decreased H3K27me3 levels in BNC cells ( Fig. 5 , B and C ; and Fig. S2 J ) ."
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"Overexpression of EZH2 is reported in a range of malignancies, and a link between BAP1 loss and overexpression of EZH2 suggests a role for the PRC2 pathway and H3K27 hypermethylation in mesothelioma development and progression (122)."
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"Loss of BAP1 leads to reduced L3MBTL2 stability and increased EZH2 transcriptional output in mesothelioma [XREF_BIBR]."
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"Concomitant Bap1 and Ezh2 loss reduced myeloid progenitor expansion, reduced the proportion of Mac1 + Gr1 + myeloid cells, restored erythroid differentiation (CD71 + Ter119 +) and decreased proliferation of Bap1 and Ezh2 deficient progenitors (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Loss of BAP1 has been shown to be synthetically lethal with inhibition of EZH2 or PRC2."
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"To that end, a systematic literature review was performed of articles dealing with a loss of BRCA1-associated protein 1 (BAP1), methylthioadenosine (MTAP), 5-hydroxymethylcitosine (5-hmC), glucose transporter 1 (GLUT1), insulin like-growth factor II messenger RNA-binding protein 3 (IMP3), enhanced zeste homologue 2 (EZH2) staining, cyclin-dependent kinase inhibitor 2A (CDKN2A) homozygous deletion (HD) testing, soluble mesothelin, and microRNA quantification in cytological samples for the diagnosis of MPM versus reactive atypical mesothelial cells."
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"BAP1 loss leads to increased expression of EZH2 ( 15 ) ."
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"As for the reported tumor suppressive mechanism, BAP1 can antagonize EZH2 and PRC2 or RING1B (RNF2)/PRC1 in a tissue specific manner."
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"LaFave et al. [XREF_BIBR] reported that loss of BAP1 promotes MPM cell proliferation by upregulating EZH2."
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