IndraLab

Statements


USP22 increases the amount of H2AX. 3 / 3
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"The expression of H2AFX (H2A histone family, member X) histone was promoted by USP22 (Ubiquitin-specific protease 22), which was involved in the occurrence and progression of LUAD [48]."

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"USP22 induces the occurrence and development of LUAD by promoting the expression of H2AFX histone."

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"However, formation of γH2AX may require dynamic regulation of H2B monoubiquitination, as loss of the H2B-specific deubiquitinase USP22 led to reduced levels of γH2AX (11)."