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KCNMA1 activates CRBN. 2 / 2
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"To demonstrate the reduced BK activity accounts for the impaired learning and memory of the CRBN mutant mice, we performed the Morris water maze tests on Crbn F/F; Nestin-Cre mice treated with a BK channel opener, BMS-204352 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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"Thus, we investigated whether other known Crbn substrates, namely, Slo, glutamate synthetase, CIC-1/2, and MEIS2, mediate the effects of Crbn on efferocytosis by cells overexpressing each substrate or pharmacological approaches."