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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNMA1 activates CRBN. 2 / 2

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"Thus, we investigated whether other known Crbn substrates, namely, Slo, glutamate synthetase, CIC-1/2, and MEIS2, mediate the effects of Crbn on efferocytosis by cells overexpressing each substrate or pharmacological approaches."

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"To demonstrate the reduced BK activity accounts for the impaired learning and memory of the CRBN mutant mice, we performed the Morris water maze tests on Crbn F/F; Nestin-Cre mice treated with a BK channel opener, BMS-204352 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...