IndraLab

Statements

USP22 inhibits Carcinogenesis. 3 / 4
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"Interestingly, USP22 deletion, rather than overexpression, has been shown to drive tumorigenesis in colorectal cancer and myeloid leukemia."
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"Therefore, our results from the mouse xenograft model demonstrate that USP22 silencing inhibits NSCLC tumorigenesis in vivo through regulating the MDMX–p53 pathway."
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"Consistently, overexpression of USP22 stimulates while downregulation of USP22 suppresses breast cancer cell growth, migration and tumorigenesis in a MYC dependent manner.113 USP13."
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