IndraLab

Statements

Testosterone inhibits NFKB1. 3 / 3
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"The beneficial effects may be mediated by up-regulation of testosterone production, which in turn inhibits NFkB activation, leading to decreased cytokine and chemokine production and decreased chemotactic activity of leukocytes."
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"For instance, studies have shown that testosterone can suppress NF-KB signaling, thereby inhibiting P65 signaling (NF-kB and p65 are associated with the production of pro-inflammatory cytokines and the pathogenesis of many inflammatory diseases), leading to a reduction in pro-inflammatory markers such as TNF-α, IL-2, among others ."
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"FOXO3A is implicated in the regulation of NFkB inhibitors [XREF_BIBR], while estrogen [XREF_BIBR] and testosterone [XREF_BIBR] have also been shown to inhibit NFkB activity."
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