IndraLab

Statements

OTUB1 inhibits UBE2D1. 8 / 10
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sparser
"In this study, we sought to elucidate the structural mechanism by which OTUB1 recognizes and inhibits UBC13, UbcH5 and related E2 enzymes."
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trips
"Otub1 regulates p53 stability and activity via non-canonical inhibition of UbcH5, the MDM2 cognate ubiquitin-conjugating enzyme (E2)."
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"17 OTUB1 also suppresses UBCH5 E2 enzyme and stabilizes the p53 protein."
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sparser
"It has been reported that OTUB1 non-catalytically inhibits UBE2D proteins from ubiquitinating p53 xref , xref and SMAD2/3, regulators of TGFβ signaling xref ."
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sparser
"One such example is OTUB1 which can inhibit UbcH5."
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eidos
"OTUB1 has also been shown to noncatalytically inhibit UBCH5 in vitro ( 18 ) and in cells ( 21 ) ."
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reach
"One such example is OTUB1 which can inhibit UbcH5."
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reach
"Monoubiquitination is critical for ovarian tumor domain containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein."
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