IndraLab

Statements

OTUB1 inhibits UBE2D1. 11 / 13
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"One such example is OTUB1 which can inhibit UbcH5."
25962961
sparser
"In this study, we sought to elucidate the structural mechanism by which OTUB1 recognizes and inhibits UBC13, UbcH5 and related E2 enzymes."
22325355
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"Monoubiquitination of OTUB1 was found to suppress UbcH5 activity, thereby stabilizing p53 [85] ."
29864528
sparser
"One such example is OTUB1 which can inhibit UbcH5."
25962961
trips
"Otub1 regulates p53 stability and activity via non-canonical inhibition of UbcH5, the MDM2 cognate ubiquitin-conjugating enzyme (E2)."
28035068
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"Monoubiquitination of OTUB1, primarily at lysines 59 and 109, is critical for OTUB1 function to suppress UbcH5 and induce p53, and the DUB activity of Ataxin-3 and JOSD1 can be enhanced through ubiquitination of lysine 117 on Ataxin-3 and lysine 136 on JOSD1."
37642399
sparser
"It has been reported that OTUB1 non-catalytically inhibits UBE2D proteins from ubiquitinating p53 xref , xref and SMAD2/3, regulators of TGFβ signaling xref ."
32049508
sparser
"Instead, OTUB1 binds and inhibits UbcH5 (UBE2D family), the cognate E2 for MDM2 which is a key E3 ligase for P53."
38264570
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"Monoubiquitination is critical for ovarian tumor domain containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein."
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"17 OTUB1 also suppresses UBCH5 E2 enzyme and stabilizes the p53 protein."
26148240
eidos
"OTUB1 has also been shown to noncatalytically inhibit UBCH5 in vitro ( 18 ) and in cells ( 21 ) ."
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