IndraLab

Statements

Tetrodotoxin inhibits SCN5A. 4 / 4
1 | 1 2
eidos
"The characteristic low affinity for block of NaV1.5 by TTX is a hallmark of sodium channel pharmacology ."
31866066
reach
"The voltage gated sodium channel family is comprised of ten members : SCN1A (Nav1.1), SCN2A (Nav1.2; SCN2A1 in mouse), SCN3A (Nav1.3), SCN4A (Nav1.4), SCN8A (Nav1.6), and SCN9A (Nav1.7) are blocked by tetrodotoxin, whereas SCN5A (Nav1.5), SCN7A (Nax), SCN10A (Nav1.8), and SCN11A (Nav1.9) are not blocked by tetrodotoxin [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
19284629
ctd
No evidence text available
17978865
reach
"Further, we note the difference between sodium currents in hCICs and cardiomyocytes—I in hCIC is mainly encoded by Nav1.3 and Nav1.6, and is very sensitive to inhibition by TTX in the nanomolar range, whereas human cardiac myocyte I (Nav1.5) is usually blocked by TTX in the micromolar range (Zhang et al., 2014)."
35046835