IndraLab

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Pyruvic acid inhibits NLRP3. 15 / 15
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"Ethyl pyruvate specifically inhibits the NLRP3 inflammasome activation."
30134814
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"These results suggest that inhibition of pyruvate oxidation pathway augments lactate production and thereby enhances NLRP3 inflammasome activation."
33854503
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"Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-kappaB/miR -223 Signaling."
34066647
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"Inhibition of the Pyruvate Oxidation Pathway Augments Lactate Production and Enhances NLRP3 Inflammasome Activation."
33854503
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"Though whether cytosolic oxidized mitochondrial DNA is a bona fide NLRP3 ligand requires further investigation, our findings suggest that ethyl pyruvate inhibits the NLRP3 inflammasome activation, at least in part, through preventing mitochondrial damage."
30134814
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"To determine whether ethyl pyruvate (EP) inhibits the NLRP3 inflammasome activation, LPS primed mouse peritoneal macrophages were stimulated with ATP in the presence or the absence of different concentrations of EP."
30134814
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"We hypothesized that blocking of mitochondrial pyruvate metabolism enhanced NLRP3 inflammasome activation through altered pyruvate utilization in the cytoplasm."
33854503
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"Inhibition of pyruvate oxidation reprograms pyruvate metabolism from pyruvate driven mitochondrial respiration to cytoplasmic lactic acid fermentation and consequently enhances NLRP3 inflammasome activation."
33854503
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"Pyruvate supplementation had no effect on inflammasome signaling induced by the NLRP3 activators ATP and nigericin (XREF_FIG), indicating that pyruvate does not impair NLRP3 inflammasome signaling by a nonspecific mechanism."
27011353
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"These observations suggest that ethyl pyruvate inhibits the NLRP3 inflammasome activation through affecting the downstream signal of potassium efflux."
30134814
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"We previously found that ethyl pyruvate (EP), a metabolite derivative, is able to effectively inhibit the NLRP3 inflammasome activation."
32517686
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"Mechanistically, ethyl pyruvate inhibits the NLRP3 inflammasome activation, at least in part, by reducing mitochondrial damage."
30134814
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"Given that infection with S. typhimurium is an activator of the NLRP3 inflammasome 37 and that S. typhimurium mediated NLRP3 activation can be abrogated by pyruvate supplementation 34, this metabolic signature may constitute an important signal in inflammasome activation."
27508077
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"Inhibition of pyruvate oxidation reprograms pyruvate metabolism from mitochondrial pyruvate driven respiration to cytoplasmic lactic acid fermentation and thus enhances NLRP3 inflammasome activation."
33854503
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"Our study suggests that ethyl pyruvate effectively suppresses the NLRP3 inflammasome activation in microglial cells regulation by miR-223 and NF-kappaB and HMGB1 axis."
34066647