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USP45 inhibits F_actin. 3 / 3
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"We next examined whether the F-actin patches induced by USP45 depletion were required for the translocalization of V-ATPase to lysosomes."
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"The F-actin patches induced by USP45 knockdown highly colocalized with the late endosomal marker Rab7 and the lysosomal marker LAMP1, but not with the early endosomal marker EEA1 (Fig. 6, C and D), suggesting a role for cytosolic F-actin patches in regulating endolysosomal activity."
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"Indeed, the F-actin patches induced by USP45 depletion showed high colocalization with LysoTracker-positive acidic lysosomes (Fig. S4 A)."
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