IndraLab

Statements

USP3 activates MYCN. 2 / 2

| 2

reach

"ALYREF and MYCN form a transcriptional activator complex, which upregulates USP3 expression, promoting the growth and tumorigenicity of MYCN-amplified neuroblastoma cells [24]."

37537569

➶

reach

"Nagy et al. reported that USP3 promotes neuroblastoma cell viability, proliferation, and xenograft tumor growth by cleaving K48‐ and K63‐linked ubiquitin chains of MYCN (Figure 2C, right)."

38651282

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP3 activates MYCN. 2 / 2

INDRA sources:

Databases

Reading