IndraLab

Statements

BAP1 inhibits Osteosarcoma. 4 / 4
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"In this study, the roles of BAP1 in potential targets, biological functions, signaling pathways, and immune infiltration were comprehensively explored by mining the osteosarcoma datasets from GEO and TARGET databases using the rapidly developing bioinformatics in recent years.In summary, through bioinformatics and in vitro assays, this study demonstrated that BAP1 was a tumor suppressor in osteosarcoma and provided new clues for osteosarcoma treatment such as BAP1-targeted therapy."
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"BAP1 suppressed osteosarcoma cell growth and EMT."
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"In vitro, BAP1 could inhibit osteosarcoma cells proliferation and EMT.BAP1 belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinases (27)."
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"BAP1 might be a tumor suppressor in osteosarcoma and a promising therapeutic target."
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