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"Lastly, we are making great efforts to generate a mutant Dub strain with dapF (encodes essential diaminopimelate epimerase for Lys biosynthesis) depletion, which will enable us to mechanistically dissect the specific role of Dub-synthesized Lys for mitigating DSS-induced colitis.In summary, our comprehensive analysis demonstrates a previously unrevealed role of Dub in activating the AhR-IDO1-Kyn circuit in DCs, which improved the unbalanced Treg/Th17 response to ameliorate both mucosal and systemic inflammation in DSS-induced colitis."