IndraLab

Statements

TP53 activates USP28. 3 / 3
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"In 2 out of 3 cell line screens, the fitness attenuation effect of TP53-/- background cells was stronger in USP28 than in the neighboring ATM gene, supporting the causal role of USP28 in that segment (Additional file 3: Data S5)."
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"Moreover, purified USP28 was found to directly deubiquitinate p53 in vitro (XREF_FIG), raising potentially a direct role of USP28 in stabilizing p53 in vivo."
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"Homozygosity of either Usp28 or 53bp1 loss reduced p53 activation and rescued brain size in both Sas4 and Cep63 microcephaly models ( xref )."
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