IndraLab

Statements


MTOR phosphorylates IRS1 on S636. 14 / 14
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reach
"Therefore, mTOR phosphorylates IRS-1 Ser 636/639 to control increasing concentrations of glucose in an insulin independent manner and suppresses IRS-1 associated PI3K and Akt signaling."

reach
"MTOR and its downstream effector S6K1 suppress IRS1 activity by directly phosphorylating IRS1 at Ser636 and Ser639 and Ser307, respectively, which leads to desensitization of insulin signaling."

reach
"MTor signaling leads to phosphorylation of IRS-1 on serine 636, which serves as a negative feedback loop to decrease activation of the PI3K and Akt pathway."

reach
"Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1 ser636 phosphorylation and normalized insulin sensitivity."

sparser
"IRS-1 is phosphorylated at S636 by mTOR ( xref )."

"Mtor induced the serine phosphorylation of irs-1 (ser-636/639), and such phosphorylation was inhibited by rapamycin. These results suggest that tnf impairs insulin signaling through irs-1 by activation of a pi 3-kinase/akt/mtor pathway, which is antagonized by pten"

reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."

reach
"These include mammalian target of rapamycin (mTOR)-mediated phosphorylation of IRS1 serine 636 (Ser636) and serine 639 (Ser639), ribosomal S6 kinase 1 (S6K1)-mediated phosphorylation of IRS1 serine 307 [Ser307 (mouse serine 302) (Ser302)] and serine 1101, IkappaB kinase beta (IKKbeta) - and c-Jun N-terminal kinase (JNK)-mediated phosphorylation of IRS1 serine 312 [Ser312 (mouse Ser307)], and protein kinase zeta mediated phosphorylation of IRS1 serine 323 (mouse serine 318)."

reach
"Since IRS-1 Ser636 phosphorylation is increased by mTOR activation, the investigators proceeded to demonstrate that nicotine acutely increases mTOR activation in cultured myotubes."

reach
"MTOR induced the serine phosphorylation of IRS-1 (Ser 636/639), and such phosphorylation was inhibited by rapamycin."

reach
"Inhibition of mTOR and S6K1 by HM-chromanone significantly reduced IRS-1 Ser307 and IRS-1 Ser632 phosphorylation, leading to insulin resistance."

rlimsp
"At the molecular level, Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR."

reach
"The mTOR complex (C) 1/S6K1 blocker rapamycin inhibited the phosphorylation of IRS-1 at Ser636 in cells overexpressing alpha-Syn, suggesting that mTORC1 and S6K1 activation by alpha-Syn causes feedback inhibition of insulin signaling via suppression of IRS-1 function."

reach
"At the molecular level, Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."