IndraLab

Statements

MTOR phosphorylates IRS1 on S636. 12 / 15
1 1 | 11 1 1
reach
"MTOR induced the serine phosphorylation of IRS-1 (Ser 636/639), and such phosphorylation was inhibited by rapamycin."
11287630
reach
"Therefore, mTOR phosphorylates IRS-1 Ser 636/639 to control increasing concentrations of glucose in an insulin independent manner and suppresses IRS-1 associated PI3K and Akt signaling."
33467535
reach
"Inhibition of mTOR and S6K1 by HM-chromanone significantly reduced IRS-1 Ser307 and IRS-1 Ser632 phosphorylation, leading to insulin resistance."
36337245
reach
"MTOR and its downstream effector S6K1 suppress IRS1 activity by directly phosphorylating IRS1 at Ser636 and Ser639 and Ser307, respectively, which leads to desensitization of insulin signaling."
18949383
reach
"Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1 ser636 phosphorylation and normalized insulin sensitivity."
22966072
reach
"These include mammalian target of rapamycin (mTOR)-mediated phosphorylation of IRS1 serine 636 (Ser636) and serine 639 (Ser639), ribosomal S6 kinase 1 (S6K1)-mediated phosphorylation of IRS1 serine 307 [Ser307 (mouse serine 302) (Ser302)] and serine 1101, IkappaB kinase beta (IKKbeta) - and c-Jun N-terminal kinase (JNK)-mediated phosphorylation of IRS1 serine 312 [Ser312 (mouse Ser307)], and protein kinase zeta mediated phosphorylation of IRS1 serine 323 (mouse serine 318)."
18949383
reach
"At the molecular level, Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of IRS-1 and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."
19561084
reach
"MTor signaling leads to phosphorylation of IRS-1 on serine 636, which serves as a negative feedback loop to decrease activation of the PI3K and Akt pathway."
23816396
reach
"Since IRS-1 Ser636 phosphorylation is increased by mTOR activation, the investigators proceeded to demonstrate that nicotine acutely increases mTOR activation in cultured myotubes."
23172960
reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."
24576065
reach
"Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser 636/639 by mTOR."
19561084
sparser
"IRS-1 is phosphorylated at S636 by mTOR ( xref )."
29496905