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Interferon activates USP15. 2 / 2

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"Together, these results suggest that USP15 is not induced by IFN or viral infection, but instead is recruited to TRIM25 upon viral infection."

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"In contrast to these host- or virus encoded DUBs that inhibit RIG-I signaling, our study identifies USP15 as a positive regulator of the TRIM25-RIG-I signaling pathway, which is required for a sustained, IFN mediated antiviral response."

24399297

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IndraLab

Statements

Interferon activates USP15. 2 / 2

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