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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Interferon activates USP15. 2 / 2

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"Together, these results suggest that USP15 is not induced by IFN or viral infection, but instead is recruited to TRIM25 upon viral infection."

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"In contrast to these host- or virus encoded DUBs that inhibit RIG-I signaling, our study identifies USP15 as a positive regulator of the TRIM25-RIG-I signaling pathway, which is required for a sustained, IFN mediated antiviral response."

24399297

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...