IndraLab

Statements

OTUB2 increases the amount of PFKFB3. 5 / 5
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"OTUB2 contributes to vascular calcification in chronic kidney disease via the YAP-mediated transcription of PFKFB3."
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"In the present study, we found that OTUB2-mediated YAP stabilization promotes PFKFB3 transcription, thereby accelerating VC in CKD."
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"OTUB2 facilitates PFKFB3 transcription through YAP."
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"Collectively, these data indicated that OTUB2 promotes glycolysis in VSMCs by regulating PFKFB3 expression."
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"CUT&RUN-qPCR assays showed that OTUB2 silencing suppressed the YAP/TEAD1-promoted transcription of PFKFB3."
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