IndraLab

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Spironolactone inhibits KCNH2. 5 / 5
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"Indeed, SP and its metabolite CA can directly block the HERG channels expressed in stably transfected Chinese hamster ovary cells, i.e., in the absence of aldosterone, in addition to suppressing the native I in single guinea-pig ventricular myocytes [19]."
36836569
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"Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac action potential duration and decrease the Kv11.1 (HERG) current."
15980874
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"SP decreased HERG currents in a concentration dependent manner (IC50 = 23.0 +/-1.5 micromol/L) and shifted the midpoint of the activation curve to more negative potentials (Vh = -13.1 +/-3.4 versus -18.9 +/-3.6 mV, P < 0.05) without modifying the activation and deactivation kinetics."
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"Very recently, it was demonstrated that spironolactone and its main metabolite, canrenoic acid (CA), inhibited Kv11.1 [human ether-a-go-go (HERG)] channel currents recorded in stably transfected Chine[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15749161
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"Both spironolactone (SP) and its main metabolite, canrenoic acid (CA), prolong cardiac action potential duration and decrease the Kv11.1 (HERG) current."
15980874