IndraLab

Statements

USP14 activates cisplatin. 5 / 5
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"In vitro experiment revealed that USP14 depletion markedly inhibited cell growth, cisplatin resistance, invasion and migration capabilities of HNSCC cells."
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"CCK-8 assay results showed that inhibition of USP14 by a specific inhibitor or siRNA decreased cisplatin cytotoxicity in A2780 cells."
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"Genetic knockdown or pharmacological inhibition of USP14 reversed cisplatin resistance in EOC cells and was accompanied by the decreased expression of BCL6 (Wang YQ."
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"As data shown, USP14 silencing significantly decreased the cisplatin IC50 by 4‐5 folds in these cells (Figure 3E,F)."
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"Recently, researches have revealed USP14 enhances cisplatin resistance through affecting Akt and ERK signaling pathways and accelerates cell proliferation and migration in GC."
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