IndraLab

Statements

EGFR binds KCNH2. 6 / 6
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sparser
"We demonstrate for the first time that a physical and functional interaction of hERG1 with EGF-R occurs in PDAC."
25719829
sparser
"As activating the mutations of Kras can concomitantly upregulate EGF-R and its downstream signalling pathways ( xref ), we studied such pathway, providing evidence that hERG1 interacted with EGF-R. Overall, hERG1 turned out to contribute to the control of EGF-R-triggered intracellular signalling pathways, and, by this way, to the regulation of PDAC cell proliferation and migratory activity."
25719829
sparser
"These findings are of particular interest within our research field, since we demonstrated that hERG1 channel expression is significantly associated with EGFR expression in pancreatic ductal adenocarcinomas [ xref ] and colorectal cancers [ xref ]."
30002601
reach
"As activating the mutations of Kras can concomitantly upregulate EGF-R and its downstream signalling pathways, we studied such pathway, providing evidence that hERG1 interacted with EGF-R."
25719829
sparser
"In a different setting (pancreatic ductal adenocarcinoma), we found an association and a physical interaction between Kv11.1 and EGFR, raising the possibility of designing combined treatment schedules, also involving Kv11.1 blockers ( xref )."
32508650
sparser
"The interaction between KV11.1 and EGF-R stimulates an EGF-R–dependent phosphorylation of ERK1 and ERK2, which are key signaling proteins downstream to EGF-R, and are involved in cell proliferation (Lastraioli et al., 2015)."
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