IndraLab

Statements

KCNH2 binds EGFR. 8 / 8
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"As activating the mutations of Kras can concomitantly upregulate EGF-R and its downstream signalling pathways, we studied such pathway, providing evidence that hERG1 interacted with EGF-R."
25719829
sparser
"The interaction between Kv11.1 and EGFR is based on phosphorylation/dephosphorylation reactions at the Tyr475 located on the intracellular S2-S3 loop of the channel [ 142 ]."
31108338
sparser
"We demonstrate for the first time that a physical and functional interaction of hERG1 with EGF-R occurs in PDAC."
25719829
sparser
"As activating the mutations of Kras can concomitantly upregulate EGF-R and its downstream signalling pathways ( xref ), we studied such pathway, providing evidence that hERG1 interacted with EGF-R. Overall, hERG1 turned out to contribute to the control of EGF-R-triggered intracellular signalling pathways, and, by this way, to the regulation of PDAC cell proliferation and migratory activity."
25719829
sparser
"Indeed, it has been reported that EGFR forms a multimeric complex with hERG channels, such as Kv11.1 [ 13 ]."
36220288
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"In a different setting (pancreatic ductal adenocarcinoma), we found an association and a physical interaction between Kv11.1 and EGFR, raising the possibility of designing combined treatment schedules, also involving Kv11.1 blockers ( xref )."
32508650
sparser
"These findings are of particular interest within our research field, since we demonstrated that hERG1 channel expression is significantly associated with EGFR expression in pancreatic ductal adenocarcinomas [ xref ] and colorectal cancers [ xref ]."
30002601
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"The interaction between Kv11.1 and EGFR is based on phosphorylation/dephosphorylation reactions at the Tyr475 located on the intracellular S2-S3 loop of the channel [ 142 ]."
31108338