IndraLab

Statements


USP4 activates BRCA1. 2 / 2
| 2

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"The results showed that overexpression of USP4 induced significant upregulation of BRCA1 protein, whereas other DUBs including USP9X had little effect (Fig. 1a and Supplementary Fig. 1a–d)."

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"Overexpression of wild-type USP4 prolonged the half-life of BRCA1, whereas the catalytic-inactive mutant of USP4 (C311A) had no such effects (Fig. 1f)."