IndraLab

Statements

Mitoxantrone binds USP15. 4 / 4
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"Crystal structure analysis by Ward et al. highlighted minute differences between the paralogs and noted that mitoxantrone binds and partially inhibits USP15, similar to USP11."
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"The crystal structure of the USP15-mitoxantrone complex revealed predominantly hydrophobic interactions between mitoxantrone and USP15 residues Tyr855, Gly856, Gly860, and His862, which are located near the catalytic Cys269 [245].2-DGIn cancer, 2-deoxy-d-glucose (2-DG) interferes with D-glucose metabolism to decrease its proliferation [246]."
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"Moreover, we report that USP15 is weakly inhibited by the antineoplastic agent mitoxantrone in vitro A USP15 and mitoxantrone complex structure disclosed that the anthracenedione interacts with the S1 ' binding site."
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"Mitoxantrone was bound to USP15 as seen before in PDB: 6GH9 ( Ward et al., 2018 ) at the S1′ region near the catalytic histidine in one of the two USP15 monomers in the asymmetric unit ( Fig. 1 B)."
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