IndraLab

Statements

AZA inhibits KCNH2. 2 / 2
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"In order to evaluate the functional implications of AZA induced hERG blockage and other cardiotoxic effects not related to hERG, AZA-2 was selected due to its higher toxicity and higher hERG blocking potency."
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"AZA interacts with the channel 's central pore (F656) within the S6 transmembrane domain and physically blocks the potassium-conductance pathway of the hERG1 channels [XREF_BIBR]."
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